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|Boiling Point:||205 ℃||Usage:||It Affects Almost Every Physiological Process In The Body, Including Growth And Development, Metabolism, Body Temperature, And Heart Rate, Such As, Treatment Of Depressive Disorders And Use As A Fat Loss Supplement.|
1 ) CAS NO : 55-06-1
2 ) EINECS : 200-223-5
3 ) Chemical name : 3,3',5-Triiodo-L-thyronine, sodium salt
4 ) Molecular formula : C15H11I3NNaO4
5 ) Molecular Weight : 690.9706
6 ) Assay : 99%
7 ) Boiling point : 205 ℃
9 ) Usage : It affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate, such as, treatment of depressive disorders and use as a fat loss supplement.
A . Treatment of depressive disorders:
The addition of triiodothyronine to existing treatments such as SSRIs is one of the most widely studied augmentation strategies for refractory depression,however success may depend on the dosage of T3. A long-term case series study by Kelly and Lieberman of 17 patients with major refractory unipolar depression found that 14 patients showed sustained improvement of symptoms over an average timespan of two years, in some cases with higher doses of T3 than the traditional 50 µg required to achieve therapeutic effect, with an average of 80 µg and a dosage span of 24 months; dose range: 25-150 µg.The same authors published a retrospective study of 125 patients with the two most common categories of bipolar disorders II and NOS whose treatment had previously been resistant to an average of 14 other medications. They found that 84% experienced improvement and 33% experienced full remission over a period of an average of 20.3 (standard deviation of 9.7). None of the patients experienced hypomania while on T3.
B . Use as a fat loss supplement:
3,5-Diiodo-L-thyronine and 3,3'-diiodo-L-thyronine are used as ingredients in certain over-the-counter fat-loss supplements, designed for bodybuilding. Several studies have shown that these compounds increase the metabolization of fatty acids and the burning of adipose fat tissue in rats.
Triiodothyronine, also known as T3, is a thyroid hormone. It affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate.
A . Protein
T3 stimulates the production of RNA Polymerase I and II and, therefore, increases the rate of protein synthesis. It also increases the rate of protein degradation, and, in excess, the rate of protein degradation exceeds the rate of protein synthesis. In such situations, the body may go into negative ion balance.
B . Glucose
T3 potentiates the effects of the β-adrenergic receptors on the metabolism of glucose. Therefore, it increases the rate of glycogen breakdown and glucose synthesis in gluconeogenesis.
C . Lipids
T3 stimulates the breakdown of cholesterol and increases the number of LDL receptors,thereby increasing the rate of lipolysis.
D . Heart
T3 increases the heart rate and force of contraction, thus increasing cardiac output, by increasing β-adrenergic receptor levels in myocardium.This results in increased systolic blood pressure and decreased diastolic blood pressure. The latter two effects act to produce the typical bounding pulse seen in hyperthyroidism.
|Appearance||An odorless, almost white or buff colored powder||pass|
|Solubility||1,Very slightly soluble in water||pass|
|2,slightly soluble in alcohol||pass|
|3,practically insoluble in most other organic solvents||pass|
|4,disolves in diluted aqueous sodium hydroxide solutions||Pass|
|Identification||a) Heat about 50 mg with a few drops of sulfuric acid in a porcelain crucible: violet vapors of iodine are evolved.||pass|
|b)The retention time of the major peak is confirm to the RS||pass|
|Loss on Drying||Not more than 4.0%||0.46%|
|+18 ~ +22o||＋20.9o|
|Assay(HPLC)||Not less than 95.0%||99.18%|
|Levothyroxine sodium||Not more than 5.0%||0.68%|
|Conclusion:||Up to the Standard for Export|
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