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|Name:||L-Thyroxine||Alias:||Levothyroxine; L-Epinephrine HCl; Epinephrine Hydrochloride; L-adrenaline Hydrochloride; (R)-adrenaline Hydrochloride|
|MW:||776.87||Appearance:||White Crystalline Powder|
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CAS 51-48-9 L-thyroxine T4 Weight Loss Steroids Muscle Gaining T4 Epinephrine Hydrochloride
1). Thyroid hormone drugs are natural or synthetic preparations containing tetraiodothyronine (T4, levothyroxine) sodium or triiodothyronine (T3, liothyronine) sodium or both. T4 and T3 are produced in the human thyroid gland by the iodination and coupling of the amino acid tyrosine. T4 contains four iodine atoms and is formed by the coupling of two molecules of diiodotyrosine (DIT). T3 contains three atoms of iodine and is formed by the coupling of one molecule of DIT with one molecule of monoiodotyrosine (MIT).
2). Levothyroxine or L-thyroxine is a synthetic thyroid hormone that is chemically identical to thyroxine (T4), which is naturally secreted by the follicular cells of the thyroid gland. It is used to treat thyroid hormone deficiency, and occasionally to prevent the recurrence of thyroid cancer. Like its naturally secreted counterpart, levothyroxine is a chiral compound in the L-form. The related drug dextrothyroxine (D-thyroxine) was used in the past as a treatment for hypercholesterolemia (elevated cholesterol levels) but was withdrawn due to cardiac side effects.
3). Levothyroxine is typically used to treat hypothyroidism, and is the treatment of choice for patients with hypothyroidism, who often require lifelong thyroid hormone therapy. It may also be used to treat goiter via its ability to lower thyroid-stimulating hormone (TSH), a hormone that is considered goiter-inducing. Levothyroxine is also used as interventional therapy in patients with nodular thyroid disease or thyroid cancer to suppress thyroid-stimulating hormone (TSH) secretion. In 1992, President George H.W. Bush told television host Larry King that he had been prescribed levothyroxine as part of a treatment regimen for Graves' disease.
Levothyroxine for systemic administration is available as an oral tablet, an intramuscular injection and as a solution for intravenous infusion. Furthermore, levothyroxine is available as both brand-name and generic products. While the United States Food and Drug Administration (FDA) approved the use of generic levothyroxine for brand-name levothyroxine in 2004, the decision was met with disagreement by several medical associations.
Side effects: this medication should not be used for weight loss. Normal doses of this medication will not work for weight loss and large doses of this medication may cause serious, possibly fatal side effects, especially when taken with diet pills.
|Appearance||An odorless, almost white or buff colored powder||pass|
|Solubility||1,Very slightly soluble in water||pass|
|2,slightly soluble in alcohol||pass|
|3,practically insoluble in most other organic solvents||pass|
|4,disolves in diluted aqueous sodium hydroxide solutions||Pass|
|Identification||a) Heat about 50 mg with a few drops of sulfuric acid in a porcelain crucible: violet vapors of iodine are evolved.||pass|
|b)The retention time of the major peak is confirm to the RS||pass|
|Loss on Drying||Not more than 4.0%||0.46%|
|+18 ~ +22o||＋20.9o|
|Assay(HPLC)||Not less than 95.0%||99.18%|
|Levothyroxine sodium||Not more than 5.0%||0.68%|
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