Health Weight Loss Steroids For Men DNP 2, 4-dinitrophenol Powder CAS 51-28-5

Health Weight Loss Steroids For Men DNP 2, 4-dinitrophenol Powder CAS 51-28-5

Quick Detailed: 

Pharmaceutical raw material dnp supplier 2, 4-Dinitrophenol
Alias: DNP
Sales.Rep:eva.pharmade
CAS No: 51-28-5
MF: C6H4N2O5
MW: 184.11
Purity: 98%
Package: 1kg/foil bag
Appearance: Buff monoclinic crystal. Soluble in hot water, ethanol,
ethyl ether, acetone, toluene, benzene, chloroform and pyridine insoluble in cold water.
Can with water vapor volatilization, heated sublimation. 

Description:

DNP, its role is to make the de-coupling of oxidation and phosphorylation. Once given to 10-4M concentration of mitochondria, the uncoupling effect occurs, oxygen absorption is increased, P: O decline, if further given the high concentration will hinder the absorption of oxygen. DNP as a mechanism of action uncoupler is: DNP did not inhibit transfer of electrons, but it can eliminate the proton driving force required for the synthesis of ATP. Since DNP is a lipophilic compound is weakly acidic, it passes through the neutral state proton mitochondrial inner membrane lipid bilayer. When there is a proton gradient across the membrane, it is incorporated in the acidic side of the membrane proton to become a neutral state uncharged, by diffusion through the membrane, and in the alkaline side of the membrane to release a proton, thereby neutralized cross membrane proton gradient.

Application:

DXM is also used recreationally. When exceeding label-specified maximum dosages, dextromethorphan acts as a dissociative hallucinogen. Its mechanism of action is via multiple effects, including actions as a nonselective serotonin reuptake inhibitor and a sigma-1 receptor agonist. The major metabolite of DXM, dextrorphan, also acts as an NMDA receptor antagonist. In high doses this produces effects similar to, yet distinct from, the dissociative states created by other dissociative anaesthetic such as ketamine and phencyclidine. As well, the metabolite 3-methoxymorphinan of dextrorphan (thus a second-level metabolite of DXM) produces local anesthetic effects in rats with potency above dextrorphan, but below that of DXM.

DNP in the human body is a proton carrier, protons into the mitochondrial inner membrane can be skipped ATP synthase. This makes the efficiency of ATP synthesis becomes low - in fact, part of cellular respiration to produce energy in the form of ATP synthesis dissipation of heat. The intake efficiency of ATP synthesis with DNP is inversely proportional, so as to increase the amount of DNP, the cell in order to provide the body with enough energy supplement ATP, also will be a significant increase in metabolic rate, so that more fat is consumed. DNP is perhaps the most famous one, "uncoupler" because its role is to lift the coupling between the principle of electron transport and phosphorylation of both should be part of the normal respiratory chain, namely oxidative phosphorylation "solution coupling. "Interestingly, the amount of limitation is not due to lack of DNP ATP in the human body, but because of the large amount of heat and the consequent uncoupling of the temperature generated during a substantial rise. 

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